Translocation of tetracosahexaenoyl-CoA to peroxisomes
ATP + THA-CoA → ADP + PI + THA-CoA
- Reactome
- R-HSA-2046087
- Compartment
- endoplasmic reticulum lumen · endoplasmic reticulum membrane · peroxisomal membrane · peroxisomal matrix
- Rhea
- None recorded
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, endoplasmic reticulum membrane
- THA-CoACHEBI:63540, C45H70N7O17P3S, endoplasmic reticulum lumen
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, endoplasmic reticulum membrane
- PICHEBI:57880, C11H16O13PR2, endoplasmic reticulum membrane
- THA-CoACHEBI:63540, C45H70N7O17P3S, peroxisomal matrix
Catalysed by
- long-chain fatty acid transmembrane transporter activity of ABCD1 [peroxisomal membrane]EC 7.6.2.4; UniProt P33897
Literature
- Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid J Lipid Res, 1995
- Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis J Biol Chem, 2001
- Studies on the metabolic fate of n-3 polyunsaturated fatty acids J Lipid Res, 2003