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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

acyl-CoA + H2O → acyl-PPANT + PAP + 2 H+

Reactome: R-HSA-6810474
Compartment: peroxisomal matrix
Rhea: RHEA:50045

Inputs

acyl-CoACHEBI:58342, C22H31N7O17P3SR, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix

Outputs

acyl-PPANTCHEBI:132023, C12H20N2O8PSR, peroxisomal matrix
PAPCHEBI:58343, C10H11N5O10P2, peroxisomal matrix
2 H+CHEBI:15378, H, peroxisomal matrix

Catalysed by

coenzyme A diphosphatase activity of NUDT19 [peroxisomal matrix]EC 3.6.1.77; UniProt A8MXV4

Literature

Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity Biochem. J., 2006