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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACSM3,ACSM6 ligate CoA to BUT

BUT + ATP + CoA-SH → BT-CoA + AMP + PPi

Reactome: R-HSA-8875013
Compartment: mitochondrial matrix
Rhea: RHEA:46173

Inputs

BUTCHEBI:17968, C4H7O2, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

BT-CoACHEBI:57371, C25H38N7O17P3S, mitochondrial matrix
AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
PPiCHEBI:33019, HO7P2, mitochondrial matrix

Catalysed by

medium-chain fatty acid-CoA ligase activity of ACSM3,ACSM6 [mitochondrial matrix]EC 6.2.1.2

Literature

Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product J Biol Chem, 2001
Human SA gene locus as a candidate locus for essential hypertension Hypertension, 1994
Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension Circulation, 2002
SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study J. Hypertens., 2007
SAH gene variants revisited in the European Project On Genes in Hypertension J. Hypertens., 2008