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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MID1IP1 binds THRSP

MID1IP1 + THRSP → MID1IP1:THRSP

Reactome: R-HSA-8866941
Compartment: cytosol
Rhea: None recorded

Inputs

MID1IP1R-HSA-8867328, cytosol
THRSPR-HSA-8867326, cytosol

Outputs

MID1IP1:THRSPR-HSA-8867329, cytosol

Catalysed by

molecular function activator activity of THRSP [cytosol]UniProt Q92748

Literature

Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate Endocrinology, 2008
Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis Endocrinology, 2010
Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2 J. Mol. Recognit., 2013