Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

ETA-CoA + O2 + 2 NADH → EPA-CoA + 2 H2O + 2 NAD+

Reactome: R-HSA-2046089
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

ETA-CoACHEBI:63542, C41H66N7O17P3S, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
2 NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen

Outputs

EPA-CoACHEBI:63539, C41H64N7O17P3S, endoplasmic reticulum lumen
2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
2 NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen

Catalysed by

omega-6 fatty acid desaturase activity of FADS1 [endoplasmic reticulum membrane]UniProt O60427

Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

Inputs

Outputs

Catalysed by

Literature