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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LTA4 is converted to LTC4 by LTC4S

LTA4 + GSH → LTC4

Reactome: R-HSA-266050
Compartment: cytosol · nuclear envelope
Rhea: RHEA:17619

Inputs

LTA4CHEBI:57463, C20H29O3, cytosol
GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

LTC4CHEBI:57973, C30H45N3O9S, cytosol

Catalysed by

leukotriene-C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]EC 4.4.1.20

Literature

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4 Proc Natl Acad Sci U S A, 1994
Molecular cloning and expression of human leukotriene-C4 synthase Proc Natl Acad Sci U S A, 1994