2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP
NADPH + H+ + 3OA-ACP → NADP+ + 3HA-ACP
- Reactome
- R-HSA-8862152
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:17399
Inputs
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- 3OA-ACPCHEBI:78776, C17H26N3O10PSR, mitochondrial matrix
Outputs
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
- 3HA-ACPCHEBI:78827, C17H28N3O10PSR, mitochondrial matrix
Catalysed by
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity of 2xHSD17B8:2xCBR4 [mitochondrial matrix]EC 1.1.1.100
Literature
- Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8 Mol. Cell. Biochem., 2008
- 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS FASEB J., 2009
- Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain J. Biol. Chem., 2005
- Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase Nat Commun, 2014