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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

ICS-CoA + Mal-CoA + H+ → CoA-SH + CO2 + 3ODC-CoA

Reactome: R-HSA-548815
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:35328

Inputs

ICS-CoACHEBI:57380, C41H70N7O17P3S, cytosol
Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
H+CHEBI:15378, H, cytosol

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
CO2CHEBI:16526, CO2, cytosol
3ODC-CoACHEBI:71451, C43H72N7O18P3S, cytosol

Catalysed by

fatty acid elongase activity of ELOVL7 [endoplasmic reticulum membrane]EC 2.3.1.199; UniProt A1L3X0

Literature

Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism Cancer Res, 2009