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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX5 binds ALOX5 inhibitors

ALOX5:ALOX5AP:LTC4S + ALOX5 inhibitors → ALOX5:ALOX5 inhibitors

Reactome: R-HSA-9707186
Compartment: nuclear envelope · cytosol
Rhea: None recorded

Inputs

ALOX5:ALOX5AP:LTC4SR-HSA-2318764, nuclear envelope
ALOX5 inhibitorsR-ALL-9707237, cytosol

Outputs

ALOX5:ALOX5 inhibitorsR-HSA-9707188, nuclear envelope

Literature

5-lipoxygenase inhibitory activity of zileuton J Pharmacol Exp Ther, 1991
Zileuton, a new efficient and safe systemic anti-acne drug Dermatoendocrinol, 2009
Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production Dermatology, 2005
Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma Eur J Med Chem, 2018
Maximum Time of the Effect of Antileukotriene - Zileuton in Treatment of Patients with Bronchial Asthma Acta Inform Med, 2016
Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro Prostaglandins Leukot Med, 1986