Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

VLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi

Reactome: R-HSA-5695957
Compartment: cytosol
Rhea: RHEA:54537

Inputs

VLCFACHEBI:58950, CO2R, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

VLCFA-CoACHEBI:138261, C22H31N7O17P3SR, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]

ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

Inputs

Outputs

Catalysed by

Literature