ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA
MCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+
- Reactome
- R-HSA-5690066
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:68185, RHEA:67681
Inputs
- MCFA-CoA, LCFA-CoAR-ALL-5690540, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- MCFA, LCFAR-ALL-5690519, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- fatty acyl-CoA hydrolase activity of ACOT2,9, THEM4,5 dimer [mitochondrial matrix]EC 3.1.2.20
Literature
- New players on the metabolic stage: How do you like Them Acots? Adipocyte, 2013
- The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism Biochim. Biophys. Acta, 2012
- Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs FASEB J., 2006
- Correlation of structure and function in the human hotdog-fold enzyme hTHEM4 Biochemistry, 2012
- Functional and structural properties of mammalian acyl-coenzyme A thioesterases Prog. Lipid Res., 2010
- Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development Mol. Cell. Biol., 2012