Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD

PGD2/E2/F2a + NAD+ → 15k-PGD2,15k-PGE2,15k-PGF2a + NADH + H+

Reactome: R-HSA-2161662
Compartment: cytosol
Rhea: None recorded

Inputs

PGD2/E2/F2aR-ALL-2161661, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

15k-PGD2,15k-PGE2,15k-PGF2aR-ALL-2161597, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]EC 1.1.1.141

Literature

Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2 Bioorg Med Chem, 2006
Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits Arch Biochem Biophys, 1986