Formation of Malonyl-CoA from Acetyl-CoA (liver)
Ac-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+
- Reactome
- R-HSA-200555
- Compartment
- cytosol
- Rhea
- RHEA:11309
Inputs
- Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- HCO3-CHEBI:17544, CHO3, cytosol
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
- Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- acetyl-CoA carboxylase activity of Btn-ACACA [cytosol]EC 6.4.1.2; UniProt Q13085
Literature
- Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms Proc Natl Acad Sci U S A, 1995
- Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes Protein Expr Purif, 2007
- Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate Arch Biochem Biophys, 2008