ACSL3,4 ligate CoA to AA to form AA-CoA
AA + ATP + CoA-SH → AA-CoA + AMP + PPi + H2O
- Reactome
- R-HSA-548843
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:19714
Inputs
- AACHEBI:32395, C20H31O2, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
Outputs
- AA-CoACHEBI:57368, C41H62N7O17P3S, cytosol
- AMPCHEBI:456215, C10H12N5O7P, cytosol
- PPiCHEBI:33019, HO7P2, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]EC 6.2.1.3
Literature
- A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients J Med Genet, 2003
- FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation Nat Genet, 2002
- Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells J. Biol. Chem., 2008