PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA
2E-phytenoyl-CoA + H+ + NADPH → NADP+ + Phytanoyl-CoA
- Reactome
- R-HSA-6809810
- Compartment
- peroxisomal membrane · peroxisomal matrix
- Rhea
- RHEA:33764
Inputs
- 2E-phytenoyl-CoAR-ALL-6809811, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
- NADPHCHEBI:57783, C21H26N7O17P3, peroxisomal matrix
Outputs
- NADP+CHEBI:58349, C21H25N7O17P3, peroxisomal matrix
- Phytanoyl-CoACHEBI:57391, C41H70N7O17P3S, peroxisomal matrix
Catalysed by
- trans-2-enoyl-CoA reductase (NADPH) activity of PECR tetramer [peroxisomal membrane]EC 1.3.1.38
Literature
- Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs J. Biol. Chem., 2000
- Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation FEBS Lett., 2006
- Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism J. Lipid Res., 2010