(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H
NAD+ + 3HB-CoA → NADH + H+ + ACA-CoA
- Reactome
- R-HSA-77312
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:30800
Inputs
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
- 3HB-CoACHEBI:57316, C25H38N7O18P3S, mitochondrial matrix
Outputs
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- ACA-CoACHEBI:57286, C25H36N7O18P3S, mitochondrial matrix
Catalysed by
- (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HADH dimer [mitochondrial matrix]EC 1.1.1.35
Literature
- Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence. Biochem Biophys Res Commun, 1996
- Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism. Biochemistry, 1999