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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TECR,TECRL dehydrogenate TOD-CoA to ST-CoA

TOD-CoA + NADPH + H+ → ST-CoA + NADP+

Reactome: R-HSA-548831
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:35353

Inputs

TOD-CoACHEBI:71412, C39H64N7O17P3S, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

ST-CoACHEBI:57394, C39H66N7O17P3S, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

very-long-chain fatty acyl-CoA dehydrogenase activity of TECR,TECRL [endoplasmic reticulum membrane]EC 1.3.8.9

Literature

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade J Biol Chem, 2003