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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

propionyl-CoA + carnitine => propionylcarnitine + CoASH

propionyl CoA + CAR → Propionylcarnitine + CoA-SH

Reactome: R-HSA-390284
Compartment: peroxisomal matrix
Rhea: RHEA:44977

Inputs

propionyl CoACHEBI:57392, C24H36N7O17P3S, peroxisomal matrix
CARCHEBI:16347, C7H15NO3, peroxisomal matrix

Outputs

PropionylcarnitineCHEBI:53210, C10H19NO4, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix

Catalysed by

carnitine O-acetyltransferase activity of CRAT [peroxisomal matrix]EC 2.3.1.7; UniProt P43155

Literature

Purification and properties of carnitine acetyltransferase from human liver Eur J Biochem, 1990
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. J Biol Chem, 2003