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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1

15k-PGE2,15k-PGF2a + NADPH + H+ → dhk-PGE2,dhk-PGF2a + NADP+

Reactome: R-HSA-2161692
Compartment: cytosol
Rhea: RHEA:11914, RHEA:50590

Inputs

15k-PGE2,15k-PGF2aR-ALL-2161650, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

dhk-PGE2,dhk-PGF2aR-ALL-2161684, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

15-oxoprostaglandin 13-reductase [NAD(P)+] activity of PTGR2 [cytosol]EC 1.3.1.48; UniProt Q8N8N7

15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1

Inputs

Outputs

Catalysed by

Literature