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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is oxidised to PGG2 by PTGS1

2 O2 + AA → PGG2

Reactome: R-HSA-140355
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: RHEA:42597

Inputs

2 O2CHEBI:15379, O2, endoplasmic reticulum lumen
AACHEBI:32395, C20H31O2, endoplasmic reticulum lumen

Outputs

PGG2CHEBI:82629, C20H31O6, endoplasmic reticulum lumen

Catalysed by

prostaglandin-endoperoxide synthase activity of PTGS1 dimer [endoplasmic reticulum membrane]EC 1.14.99.1

Literature

Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation Proc Natl Acad Sci U S A, 1974
Isolation and properties of intermediates in prostaglandin biosynthesis Biochim Biophys Acta, 1973