Arachidonate is hydroxylated to 19-HETE by CYP(2)
AA + O2 + NADPH + H+ → 19-HETE + NADP+ + H2O
- Reactome
- R-HSA-2161814
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- RHEA:39760
Inputs
- AACHEBI:32395, C20H31O2, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Outputs
- 19-HETECHEBI:76627, C20H31O3, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of CYP(2) [endoplasmic reticulum membrane]
Literature
- Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes J Pharmacol Exp Ther, 1998
- Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension Circulation, 2005
- CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids J Biol Chem, 2004
- Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Drug Metab Dispos, 2004