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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA

Ac-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+

Reactome: R-HSA-8876889
Compartment: cytosol · mitochondrial outer membrane
Rhea: RHEA:11309

Inputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
HCO3-CHEBI:17544, CHO3, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

acetyl-CoA carboxylase activity of Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane]EC 6.4.1.2

Literature

Expression, purification, and characterization of human acetyl-CoA carboxylase 2 Protein Expr Purif, 2007
The subcellular localization of acetyl-CoA carboxylase 2 Proc Natl Acad Sci U S A, 2000
Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis Proc. Natl. Acad. Sci. U.S.A., 2010
Selectivity in post-translational biotin addition to five human carboxylases J. Biol. Chem., 2012
Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate Endocrinology, 2008
Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2 J. Mol. Recognit., 2013