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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H

(S)-3-Hydroxyhexadecanoyl-CoA + NAD+ → NADH + 3-Oxopalmitoyl-CoA + H+

Reactome: R-HSA-77303
Compartment: mitochondrial matrix
Rhea: RHEA:31160

Inputs

(S)-3-Hydroxyhexadecanoyl-CoACHEBI:62613, C37H62N7O18P3S, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
3-Oxopalmitoyl-CoACHEBI:57349, C37H60N7O18P3S, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of Trifunctional Protein [mitochondrial matrix]EC 1.1.1.35

Literature

Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria. Biochem Biophys Res Commun, 1992