OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol
CAR + Na+ → CAR + Na+
- Reactome
- R-HSA-165026
- Compartment
- plasma membrane
- Rhea
- RHEA:72091
Inputs
- CARCHEBI:16347, C7H15NO3, extracellular region
- Na+CHEBI:29101, Na, extracellular region
Outputs
- CARCHEBI:16347, C7H15NO3, cytosol
- Na+CHEBI:29101, Na, cytosol
Catalysed by
- carnitine transmembrane transporter activity of SLC22A5 [plasma membrane]UniProt O76082
Literature
- Genetic disorders of carnitine metabolism and their nutritional management. Annu Rev Nutr, 1998
- Carnitine transport and fatty acid oxidation Biochim. Biophys. Acta, 2016
- Mutations in novel cation transporter (OCTN2), an organic cation/carnitine transporter,with differential effects on the organic cation transport function and the carnitine transport function J Biol Chem, 1999
- Molecular and functional identification of sodium ion-dependent, high-affinity human carnitine transporter OCTN2 J Biol Chem, 1998