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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP

AMP + ATP → AMP + ATP

Reactome: R-HSA-389652
Compartment: peroxisomal membrane
Rhea: None recorded

Inputs

AMPCHEBI:456215, C10H12N5O7P, peroxisomal matrix
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

AMPCHEBI:456215, C10H12N5O7P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, peroxisomal matrix

Catalysed by

adenine nucleotide transmembrane transporter activity of SLC25A17 [peroxisomal membrane]UniProt O43808

Literature

Biochemistry of mammalian peroxisomes revisited Annu Rev Biochem, 2006
Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii Eur J Biochem, 1998
Identification of human PMP34 as a peroxisomal ATP transporter Biochem Biophys Res Commun, 2002