TXB2 is converted to 11dh-TXB2 by TXDH
TXB2 + NAD+ → 11dh-TXB2 + NADH + H+
- Reactome
- R-HSA-2161732
- Compartment
- endoplasmic reticulum lumen
- Rhea
- RHEA:52313
Inputs
- TXB2CHEBI:90696, C20H33O6, endoplasmic reticulum lumen
- NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen
Outputs
- 11dh-TXB2CHEBI:136539, C20H31O6, endoplasmic reticulum lumen
- NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Catalysed by
- 11-hydroxythromboxane B2 dehydrogenase activity of TXDH [endoplasmic reticulum lumen]
Literature
- Radioimmunoassay for 11-dehydro-TXB2: a method for monitoring thromboxane production in vivo Prostaglandins, 1986
- 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation Proc Natl Acad Sci U S A, 1986
- 11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase FEBS Lett, 1994