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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH

ATP + CoA-SH + VLCFA → AMP + PPi + VLCFA-CoA

Reactome: R-HSA-9914143
Compartment: peroxisomal matrix
Rhea: RHEA:54537

Inputs

ATPCHEBI:30616, C10H12N5O13P3, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix
VLCFACHEBI:58950, CO2R, peroxisomal matrix

Outputs

AMPCHEBI:456215, C10H12N5O7P, peroxisomal matrix
PPiCHEBI:33019, HO7P2, peroxisomal matrix
VLCFA-CoACHEBI:138261, C22H31N7O17P3SR, peroxisomal matrix

Catalysed by

very long-chain fatty acid-CoA ligase activity of SLC27A2 [peroxisomal membrane]UniProt O14975

Literature

Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism Biochem Biophys Res Commun, 1999