Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate

ATP + CoA-SH + Phytanate → AMP + Phytanoyl-CoA + PPi

Reactome: R-HSA-389622
Compartment: peroxisomal matrix
Rhea: RHEA:21381

Inputs

ATPCHEBI:30616, C10H12N5O13P3, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix
PhytanateCHEBI:37257, C20H39O2, peroxisomal matrix

Outputs

AMPCHEBI:456215, C10H12N5O7P, peroxisomal matrix
Phytanoyl-CoACHEBI:57391, C41H70N7O17P3S, peroxisomal matrix
PPiCHEBI:33019, HO7P2, peroxisomal matrix

Catalysed by

phytanate-CoA ligase activity of SLC27A2 [peroxisomal membrane]EC 6.2.1.24; UniProt O14975

Literature

Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism Biochem Biophys Res Commun, 1999