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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH

4,8-dimethylnonanoyl-CoA + CAR → 4,8-dimethylnonanoylcarnitine + CoA-SH

Reactome: R-HSA-390281
Compartment: peroxisomal matrix
Rhea: RHEA:44861

Inputs

4,8-dimethylnonanoyl-CoACHEBI:77061, C32H52N7O17P3S, peroxisomal matrix
CARCHEBI:16347, C7H15NO3, peroxisomal matrix

Outputs

4,8-dimethylnonanoylcarnitineCHEBI:84654, C18H35NO4, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix

Catalysed by

carnitine O-octanoyltransferase activity of CROT [peroxisomal matrix]EC 2.3.1.137; UniProt Q9UKG9

Literature

Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids Biochem Biophys Res Commun, 1999