Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA
delta2-THA-CoA + H2O → 1-3-hydroxy-THA-CoA
- Reactome
- R-HSA-2066778
- Compartment
- peroxisomal matrix
- Rhea
- None recorded
Inputs
- delta2-THA-CoACHEBI:65139, C45H68N7O17P3S, peroxisomal matrix
- H2OCHEBI:15377, H2O, peroxisomal matrix
Outputs
- 1-3-hydroxy-THA-CoACHEBI:65130, C45H70N7O18P3S, peroxisomal matrix
Catalysed by
- 3-hydroxyacyl-CoA dehydratase activity of HSD17B4 dimer [peroxisomal matrix]EC 4.2.1.150
Literature
- Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid J Lipid Res, 1995
- Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid J Lipid Res, 2001
- Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis J Biol Chem, 2001