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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA

delta2-THA-CoA + H2O → 1-3-hydroxy-THA-CoA

Reactome
R-HSA-2066778
Compartment
peroxisomal matrix
Rhea
None recorded

Inputs

Outputs

  • 1-3-hydroxy-THA-CoACHEBI:65130, C45H70N7O18P3S, peroxisomal matrix

Catalysed by

  • 3-hydroxyacyl-CoA dehydratase activity of HSD17B4 dimer [peroxisomal matrix]EC 4.2.1.150

Literature

  1. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid J Lipid Res, 1995
  2. Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid J Lipid Res, 2001
  3. Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis J Biol Chem, 2001