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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACBD4,5 bind MCFA-CoA and LCFA-CoA

ACBD5,(ACBD4) + MCFA-CoA, LCFA-CoA → ACBD4,5:LCFA-CoA, MCFA-CoA

Reactome: R-HSA-8848247
Compartment: peroxisomal membrane · peroxisomal matrix
Rhea: None recorded

Inputs

ACBD5,(ACBD4)R-HSA-8848234, peroxisomal membrane
MCFA-CoA, LCFA-CoAR-ALL-5690520, peroxisomal matrix

Outputs

ACBD4,5:LCFA-CoA, MCFA-CoAR-HSA-8866017, peroxisomal membrane

Catalysed by

fatty-acyl-CoA binding activity of ACBD5,(ACBD4) [peroxisomal membrane]

Literature

Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy J. Cell Biol., 2014
Atg37 regulates the assembly of the pexophagic receptor protein complex Autophagy, 2014