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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA

3-ketohexacosanoyl-CoA + CoA-SH → tetracosanoyl-CoA + Ac-CoA

Reactome: R-HSA-390250
Compartment: peroxisomal matrix
Rhea: RHEA:78641

Inputs

3-ketohexacosanoyl-CoACHEBI:73980, C47H80N7O18P3S, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix

Outputs

tetracosanoyl-CoACHEBI:65052, C45H78N7O17P3S, peroxisomal matrix
Ac-CoACHEBI:57288, C23H34N7O17P3S, peroxisomal matrix

Catalysed by

acetyl-CoA C-acyltransferase activity of ACAA1 [peroxisomal matrix]EC 2.3.1.16; UniProt P09110

Literature

Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient Biochim Biophys Acta, 1991