ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
ATP + CoA-SH + PALM → AMP + H2O + PALM-CoA + PPi
- Reactome
- R-HSA-201035
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:30752
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
- PALMCHEBI:7896, C16H31O2, cytosol
Outputs
- AMPCHEBI:456215, C10H12N5O7P, cytosol
- H2OCHEBI:15377, H2O, cytosol
- PALM-CoACHEBI:57379, C37H62N7O17P3S, cytosol
- PPiCHEBI:33019, HO7P2, cytosol
Catalysed by
- long-chain fatty acid-CoA ligase activity of ACSL1,3,5,6 [endoplasmic reticulum membrane]EC 6.2.1.3
Literature
- Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors Biochem J, 1999
- Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7 J Lipid Res, 2007
- Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing Gastroenterology, 2007