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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LTB4 is oxidised to 12-oxoLTB4 by PTGR1

LTB4 + NADP+ → 12-oxoLTB4 + NADPH + H+

Reactome: R-HSA-2161567
Compartment: cytosol
Rhea: RHEA:50609

Inputs

LTB4CHEBI:57461, C20H31O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

12-oxoLTB4CHEBI:133309, C20H29O4, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]UniProt Q14914

LTB4 is oxidised to 12-oxoLTB4 by PTGR1

Inputs

Outputs

Catalysed by

Literature