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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA

EPA-CoA + Malonyl-CoA + 2 NADPH → DPA-CoA + CO2 + CoA-SH + H2O + 2 NADP+

Reactome: R-HSA-2046100
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

EPA-CoACHEBI:63539, C41H64N7O17P3S, endoplasmic reticulum lumen
Malonyl-CoACHEBI:57384, C24H33N7O19P3S, endoplasmic reticulum lumen
2 NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen

Outputs

DPA-CoACHEBI:63541, C43H68N7O17P3S, endoplasmic reticulum lumen
CO2CHEBI:16526, CO2, endoplasmic reticulum lumen
CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
2 NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]EC 2.3.1.199

Literature

Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men* Br J Nutr, 2002
Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women Br J Nutr, 2002
Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro Prostaglandins Leukot Essent Fatty Acids, 1996