ALDH3A2-2 oxidizes pristanal to pristanate
NAD+ + Pristanal + H2O → pristanate + NADH + 2 H+
- Reactome
- R-HSA-389609
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:44017
Inputs
- NAD+CHEBI:57540, C21H26N7O14P2, peroxisomal matrix
- PristanalCHEBI:49189, C19H38O, peroxisomal matrix
- H2OCHEBI:15377, H2O, peroxisomal matrix
Outputs
- pristanateCHEBI:77268, C19H37O2, peroxisomal matrix
- NADHCHEBI:57945, C21H27N7O14P2, peroxisomal matrix
- 2 H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- aldehyde dehydrogenase (NAD+) activity of ALDH3A2-2 dimer [peroxisomal membrane]EC 1.2.1.3
Literature
- Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing J. Biol. Chem., 2007
- Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes Biochem Biophys Res Commun, 2001
- Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal J. Lipid Res., 2010
- Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization Biochim. Biophys. Acta, 1997
- Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome Chem. Biol. Interact., 2001