HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
3-hydroxyhexacosanoyl-CoA + NAD+ → 3-ketohexacosanoyl-CoA + NADH + H+
- Reactome
- R-HSA-390251
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:78637
Inputs
- 3-hydroxyhexacosanoyl-CoACHEBI:76378, C47H82N7O18P3S, peroxisomal matrix
- NAD+CHEBI:57540, C21H26N7O14P2, peroxisomal matrix
Outputs
- 3-ketohexacosanoyl-CoACHEBI:73980, C47H80N7O18P3S, peroxisomal matrix
- NADHCHEBI:57945, C21H27N7O14P2, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD17B4 dimer [peroxisomal matrix]EC 1.1.1
Literature
- Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis Am J Hum Genet, 2006
- Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase J Biochem (Tokyo), 1996
- Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein J Biochem, 1997