Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA

TPA-CoA + O2 + 2 NADH → THA-CoA + 2 H2O + 2 NAD+

Reactome: R-HSA-2046099
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

TPA-CoACHEBI:63543, C45H72N7O17P3S, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
2 NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen

Outputs

THA-CoACHEBI:63540, C45H70N7O17P3S, endoplasmic reticulum lumen
2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
2 NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen

Catalysed by

acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]EC 1.14.19.3; UniProt O95864