Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGH2 is reduced to PGF2a by AKR1C3

PGH2 + NADPH + H+ → PGF2a + NADP+

Reactome: R-HSA-2161549
Compartment: cytosol
Rhea: RHEA:45314

Inputs

PGH2CHEBI:57405, C20H31O5, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

PGF2aCHEBI:57404, C20H33O5, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

prostaglandin H2 endoperoxidase reductase activity of AKR1C3 [cytosol]UniProt P42330

Literature

cDNA cloning, expression and characterization of human prostaglandin F synthase FEBS Lett, 1999
Crystal structure of human prostaglandin F synthase (AKR1C3) Biochemistry, 2004
Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost Biochemistry, 2006