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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC27A3 ligates CoA-SH to VLCFA

ATP + CoA-SH + VLCFA → VLCFA-CoA + AMP + PPi

Reactome: R-HSA-8875077
Compartment: mitochondrial matrix
Rhea: RHEA:54537

Inputs

ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
VLCFACHEBI:58950, CO2R, mitochondrial matrix

Outputs

VLCFA-CoACHEBI:138261, C22H31N7O17P3SR, mitochondrial matrix
AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
PPiCHEBI:33019, HO7P2, mitochondrial matrix

Catalysed by

very long-chain fatty acid-CoA ligase activity of SLC27A3 [mitochondrial matrix]UniProt Q5K4L6

Literature

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome J. Lipid Res., 2007
Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells J. Biol. Chem., 2004