ALOXE3 isomerises 12R-HpETE to HXA3

12R-HpETE → HXA3

Reactome

R-HSA-8942208

Compartment

cytosol

Rhea

None recorded

Catalysed by

• hydroperoxy icosatetraenoate isomerase activity of ALOXE3 [cytosol]EC 5.4.4.7; UniProt Q9BYJ1

Literature

1. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase Proc. Natl. Acad. Sci. U.S.A., 2003
2. Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope J. Biol. Chem., 2011
3. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3 Biochim. Biophys. Acta, 2005
4. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction Int J Mol Sci, 2015