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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

8,9-EET is hydrolysed to 8.9-DHET by EPHX2

H2O + 8,9-EET → 8,9-DHET

Reactome: R-HSA-9915968
Compartment: cytosol
Rhea: RHEA:44049

Inputs

H2OCHEBI:15377, H2O, cytosol
8,9-EETCHEBI:84025, C20H31O3, cytosol

Outputs

8,9-DHETCHEBI:84032, C20H33O4, cytosol

Catalysed by

epoxide hydrolase activity of EPHX2 dimer [cytosol]EC 3.3.2.10

Literature

Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas Prostaglandins Leukot Essent Fatty Acids, 2002
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis Biochemistry, 2004