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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation

LIN-CoA + 3 FAD + 3 H2O + 3 NAD+ + 3 CoA-SH → cis,cis-3,6-Dodecadienoyl-CoA + 3 FADH2 + 3 NADH + 3 H+ + 3 Ac-CoA

Reactome: R-HSA-109339
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

LIN-CoACHEBI:57383, C39H62N7O17P3S, mitochondrial matrix
3 FADCHEBI:57692, C27H30N9O15P2, mitochondrial matrix
3 H2OCHEBI:15377, H2O, mitochondrial matrix
3 NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
3 CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

cis,cis-3,6-Dodecadienoyl-CoACHEBI:78550, C33H50N7O17P3S, mitochondrial matrix
3 FADH2CHEBI:58307, C27H33N9O15P2, mitochondrial matrix
3 NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
3 H+CHEBI:15378, H, mitochondrial matrix
3 Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix