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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Conversion of malonyl-CoA and acetyl-CoA to palmitate

Ac-CoA + 7 Mal-CoA + 14 NADPH + 14 H+ → PALM + 7 CO2 + 14 NADP+ + 8 CoA-SH + 6 H2O

Reactome: R-HSA-75872
Compartment: cytosol
Rhea: RHEA:14994

Inputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
7 Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
14 NADPHCHEBI:57783, C21H26N7O17P3, cytosol
14 H+CHEBI:15378, H, cytosol

Outputs

PALMCHEBI:7896, C16H31O2, cytosol
7 CO2CHEBI:16526, CO2, cytosol
14 NADP+CHEBI:58349, C21H25N7O17P3, cytosol
8 CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
6 H2OCHEBI:15377, H2O, cytosol

Catalysed by

fatty acid synthase activity of FASN dimer [cytosol]EC 2.3.1.85

Literature

Human fatty acid synthase: properties and molecular cloning Proc Natl Acad Sci U S A, 1995
Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res, 2003