Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA

trans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA

Reactome: R-HSA-6809263
Compartment: peroxisomal matrix
Rhea: RHEA:39213

Inputs

trans-2,3-dehydrohexacosanoyl-CoACHEBI:74281, C47H80N7O17P3S, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix

Outputs

3-hydroxyhexacosanoyl-CoACHEBI:76378, C47H82N7O18P3S, peroxisomal matrix

Catalysed by

3-hydroxyacyl-CoA dehydratase activity of EHHADH [peroxisomal matrix]EC 4.2.1.150; UniProt Q08426

Literature

Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro Biochem. Biophys. Res. Commun., 1991
Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids J. Lipid Res., 2004
Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids J. Lipid Res., 2012
Induction, immunochemical identity and immunofluorescence localization of an 80 000-molecular-weight peroxisome-proliferation-associated polypeptide (polypeptide PPA-80) and peroxisomal enoyl-CoA hydratase of mouse liver and renal cortex Biochem. J., 1981
Peroxisomal beta oxidation system of rat liver. Copurification of enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase Biochem. Biophys. Res. Commun., 1979