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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH

HXA3/B3 + H2O → TrXA3/B3

Reactome: R-HSA-2161949
Compartment: cytosol
Rhea: RHEA:50901

Inputs

HXA3/B3R-ALL-2162031, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

TrXA3/B3R-ALL-2161985, cytosol

Catalysed by

hepoxilin-epoxide hydrolase activity of HXEH [cytosol]EC 3.3.2.7

Literature

Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids J Biol Chem, 1983
Purification of hepoxilin epoxide hydrolase from rat liver J Biol Chem, 1989
Characterization of arachidonic acid metabolites through the 12-lipoxygenase pathway in human epidermis by high-performance liquid chromatography and gas chromatography/mass spectrometry Rapid Commun Mass Spectrom, 1995
Occurrence of hepoxilins and trioxilins in psoriatic lesions J Invest Dermatol, 1998