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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGH2 is degraded to 12S-HHT and MDA by TBXAS1

PGH2 → 12S-HHT + MDA

Reactome: R-HSA-2161613
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: RHEA:48645

Inputs

PGH2CHEBI:57405, C20H31O5, endoplasmic reticulum lumen

Outputs

12S-HHTCHEBI:90694, C17H27O3, endoplasmic reticulum lumen
MDACHEBI:566274, C3H4O2, endoplasmic reticulum lumen

Catalysed by

12-hydroxyheptadecatrienoic acid synthase activity of TBXAS1 [endoplasmic reticulum membrane]UniProt P24557

Literature

Substrate binding is the rate-limiting step in thromboxane synthase catalysis J Biol Chem, 2001