Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
AA-CoA + Malonyl-CoA + 2 NADPH → DTA-CoA + CO2 + CoA-SH + H2O
- Reactome
- R-HSA-2046083
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- None recorded
Inputs
- AA-CoACHEBI:57368, C41H62N7O17P3S, endoplasmic reticulum lumen
- Malonyl-CoACHEBI:57384, C24H33N7O19P3S, endoplasmic reticulum lumen
- 2 NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
Outputs
- DTA-CoACHEBI:63544, C43H70N7O17P3S, endoplasmic reticulum lumen
- CO2CHEBI:16526, CO2, endoplasmic reticulum lumen
- CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Catalysed by
- fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]EC 2.3.1.199