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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

20OH-LTB4 + NADPH + H+ + O2 → 20cho-LTB4 + NADP+ + 2 H2O

Reactome: R-HSA-2161745
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:48669

Inputs

20OH-LTB4CHEBI:57460, C20H31O5, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

20cho-LTB4CHEBI:90720, C20H29O5, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
2 H2OCHEBI:15377, H2O, cytosol

Catalysed by

20-hydroxy-leukotriene B4 omega oxidase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]

Literature

The identification and formation of 20-aldehyde leukotriene B4 J Biol Chem, 1988