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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

AA-CoA + Mal-CoA + H+ → 3ODCT-CoA + CoA-SH + CO2

Reactome: R-HSA-548800
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:36476

Inputs

AA-CoACHEBI:57368, C41H62N7O17P3S, cytosol
Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
H+CHEBI:15378, H, cytosol

Outputs

3ODCT-CoACHEBI:73852, C43H64N7O18P3S, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
CO2CHEBI:16526, CO2, cytosol

Catalysed by

fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]EC 2.3.1.199

Literature

Identification and expression of mammalian long-chain PUFA elongation enzymes Lipids, 2002
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Proc Natl Acad Sci U S A, 2010